The Shire of Campaspe is a local government area in Victoria, Australia, located in the northern part of the state. It covers an area of 4,519 square kilometres (1,745 sq mi) and in August 2021 had a population of 38,735.

Echuca is a town on the banks of the Murray River and Campaspe River in Victoria, Australia. The border town of Moama is adjacent on the northern side of the Murray River in New South Wales. Echuca is the administrative centre and largest settlement in the Shire of Campaspe. As of the 2021 census, Echuca had a population of 15,056, and the population of the combined Echuca and Moama townships was 22,568.