The Shire of Loddon is a local government area in Victoria, Australia, located in the northern part of the state. It covers an area of 6,696 square kilometres (2,585 sq mi) and in 2021 had a population of 7,759.

The Loddon River, an inland river of the north–central catchment, part of the Murray-Darling basin, is located in the lower Riverina bioregion and Central Highlands and Loddon Mallee regions of the Australian state of Victoria. The headwaters of the Loddon River rise on the northern slopes of the Great Dividing Range east of Daylesford and descend to flow north into the Little Murray River, near Swan Hill. The river is impounded by the Cairn Curran and Laanecoorie reservoirs.