The Shirley–Eustis House is a historic house located at 33 Shirley Street, Boston, Massachusetts. It is a U.S. National Historic Landmark.

William Shirley was a British Army officer and colonial administrator who served as the governor of the British American colonies of Massachusetts Bay and the Bahamas. He is best known for his role in organizing the successful capture of Louisbourg during King George's War, and for his role in managing military affairs during the French and Indian War. He spent most of his years in the colonial administration of British North America working to defeat New France, but his lack of formal military training led to political difficulties and his eventual downfall.