Shuqualak, pronounced "sugar lock", is a town in Noxubee County, Mississippi, United States. As of the 2020 census, the population was 399. That is down from 501 from the 2010 census. Three locations in Shuqualak, including most of the downtown area, are included on the National Register of Historic Places.

Noxubee County is a county located in the U.S. state of Mississippi. As of the 2020 census, its population was 10,285. Its county seat is Macon. The name is derived from the Choctaw word nakshobi meaning "to stink".