The Sidney & Lois Eskenazi Hospital is a public hospital located in Indianapolis, Indiana. The hospital is the flagship medical center for Eskenazi Health, founded in 1859 as Indiana's oldest public healthcare system. The hospital is operated by Health and Hospital Corporation of Marion County. The current hospital opened December 7, 2013, less than 1,300 feet (400 m) to the west of the original campus, replacing Wishard Memorial Hospital.

The Indiana University School of Medicine (IUSM) is a major, multi-campus medical school located throughout the U.S. state of Indiana and is the graduate medical school of Indiana University. There are nine campuses throughout the state; the principal research, educational, and medical center is located on the Indiana University–Purdue University Indianapolis (IUPUI) campus in Indianapolis. With 1,461 MD students, 195 PhD students, and 1,442 residents and fellows in the 2023–24 academic year, IUSM is the largest medical school in the United States. The school offers many joint degree programs including an MD/PhD Medical Scientist Training Program. It has partnerships with Purdue University's Weldon School of Biomedical Engineering, other Indiana University system schools, and various in-state external institutions. It is the medical school with the largest number of graduates licensed in the United States per a 2018 Federation of State Medical Boards survey with 11,828 licensed physicians.