The Siedlce Ghetto, was a World War II Jewish ghetto set up by Nazi Germany in the city of Siedlce in occupied Poland, 92 kilometres (57 mi) east of Warsaw. The ghetto was closed from the outside in early October 1941. Some 12,000 Polish Jews were imprisoned there for the purpose of persecution and exploitation. Conditions were appalling; epidemics of typhus and scarlet fever raged. Beginning 22 August 1942 during the most deadly phase of the Holocaust in occupied Poland, around 10,000 Jews were rounded up – men, women and children – gathered at the Umschlagplatz, and deported to Treblinka extermination camp aboard Holocaust trains. Thousands of Jews were brought in from the ghettos in other cities and towns. In total, at least 17,000 Jews were annihilated in the process of ghetto liquidation. Hundreds of Jews were shot on the spot during the house-to-house searches, along with staff and patients of the Jewish hospital.

Siedlce is a city in eastern Poland with 77,354 inhabitants. Situated in the Masovian Voivodeship, previously the city was the capital of a separate Siedlce Voivodeship (1975–1998). The city is situated between two small rivers, the Muchawka and the Helenka, and lies along the European route E30, around 90 kilometres (56 mi) east of Warsaw. It is the fourth largest city of the Voivodeship, and the seat of the Roman Catholic Diocese of Siedlce. Siedlce is a local educational, cultural and business center.