The Siege of Cartagena (1815) was a successful 105-day Spanish siege by combined naval and ground forces under command of General Pablo Morillo, of the Colombian city and fortress of Cartagena de Indias, defended by Republican forces under the leadership of Manuel del Castillo y Rada and José Francisco Bermúdez, between August and December 1815.

The Colombian Declaration of Independence occurred on July 20, 1810 when the Junta de Santa Fe was formed in Santa Fe de Bogota, the capital of the Spanish colonial Viceroyalty of New Granada, to govern the territory autonomously from Spain. The event inspired similar independence movements across Latin America, and triggered an almost decade-long rebellion culminating in the founding of the Republic of Colombia, which spanned present-day Colombia, mainland Ecuador, Panama, and Venezuela, along with parts of northern Peru and northwestern Brazil.