The siege of Fort Detroit was an ultimately unsuccessful attempt by North American Natives to capture Fort Detroit during Pontiac's Rebellion. The siege was led primarily by Pontiac, an Ottawa chief and military leader. This rebellion would be one of the catalysts that hastened the declaration of the Proclamation of 1763 which would eventually precipitate the events leading to the American Revolution.

Fort Pontchartrain du Détroit or Fort Detroit (1701–1796) was a fort established on the north bank of the Detroit River by the French officer Antoine de la Mothe Cadillac and the Italian Alphonse de Tonty in 1701. In the 18th century, French colonial settlements developed on both sides of the river, based on the fur trade, missions, and farms.