The siege of Grand Pré happened during Father Le Loutre's War and was fought between the British and the Wabanaki Confederacy and Acadian militia. The siege happened at Fort Vieux Logis, Grand-Pré. The native and Acadia militia laid siege to Fort Vieux Logis for a week in November 1749. One historian states that the intent of the siege was to help facilitate the Acadian Exodus from the region.

Father Le Loutre's War (1749–1755), also known as the Indian War, the Mi'kmaq War and the Anglo-Mi'kmaq War, took place between King George's War and the French and Indian War in Acadia and Nova Scotia.c On one side of the conflict, the British and New England colonists were led by British officer Charles Lawrence and New England Ranger John Gorham. On the other side, Father Jean-Louis Le Loutre led the Mi'kmaq and the Acadia militia in guerrilla warfare against settlers and British forces. At the outbreak of the war there were an estimated 2500 Mi'kmaq and 12,000 Acadians in the region.