The siege of Klis or Battle of Klis was a siege of Klis Fortress in the Kingdom of Croatia within Habsburg monarchy. The siege of the fortress, which lasted for more than two decades, and the final battle near Klis in 1537, were fought as a part of the Ottoman–Habsburg wars between the defending Croatian–Habsburg forces under the leadership of Croatian feudal lord Petar Kružić, and the attacking Ottoman army under the leadership of the Ottoman general Murat-beg Tardić.

Petar Kružić was a Croatian knez, captain, soldier and defender of Klis, and the captain of Senj.