The siege of Nijmegen was a military engagement during the Eighty Years' War and the Anglo–Spanish War which took place from 17 to 21 October 1591. The Spanish garrison in Nijmegen was besieged by a Dutch and English force under Maurice of Nassau and Francis Vere respectively and surrendered soon.

The Anglo-Spanish War (1585–1604) was an intermittent conflict between the Habsburg Kingdom of Spain and the Kingdom of England that was never formally declared. It began with England's military expedition in 1585 to what was then the Spanish Netherlands under the command of the Earl of Leicester, in support of the Dutch rebellion against Spanish Habsburg rule.