The siege of Shkodra took place from May 1478 to April 1479 as a confrontation between the Ottoman Empire and the Venetians together with the League of Lezhe and other Albanians at Shkodra and its Rozafa Castle during the First Ottoman-Venetian War (1463–1479). Ottoman historian Franz Babinger called the siege "one of the most remarkable episodes in the struggle between the West and the Crescent". A small force of approximately 1,600 Albanian and Italian men and a much smaller number of women faced a massive Ottoman force containing artillery cast on site and an army reported to have been as many as 350,000 in number. The campaign was so important to Mehmed the Conqueror that he came personally to ensure triumph. After nineteen days of bombarding the castle walls, the Ottomans launched five successive general attacks which all ended in victory for the besieged. With dwindling resources, Mehmed attacked and defeated the smaller surrounding fortresses of Žabljak Crnojevića, Drisht, and Lezha, left a siege force to starve Shkodra into surrender, and returned to Constantinople. On January 25, 1479, Venice and Constantinople signed a peace agreement that among other concessions ceded Shkodra to the Ottoman Empire. The defenders of the citadel emigrated to Venice, whereas many Albanians from the region retreated into the mountains. Shkodra then became a seat of the newly established Ottoman sanjak, the Sanjak of Scutari. The Ottomans held the city until Montenegro captured it in April 1913, after a six-month siege.

Mehmed II, commonly known as Mehmed the Conqueror, was twice the sultan of the Ottoman Empire from August 1444 to September 1446 and then later from February 1451 to May 1481.