The Sierra Nevada is a mountain range in the Western United States, between the Central Valley of California and the Great Basin. The vast majority of the range lies in the state of California, although the Carson Range spur lies primarily in Nevada. The Sierra Nevada is part of the American Cordillera, an almost continuous chain of mountain ranges that forms the western "backbone" of the Americas.

The Great Basin is the largest area of contiguous endorheic watersheds, those with no outlets to the ocean, in North America. It spans nearly all of Nevada, much of Utah, and portions of California, Idaho, Oregon, Wyoming, and Baja California. It is noted for both its arid climate and the basin and range topography that varies from the North American low point at Badwater Basin in Death Valley to the highest point of the contiguous United States, less than 100 miles (160 km) away at the summit of Mount Whitney. The region spans several physiographic divisions, biomes, ecoregions, and deserts.