Sierra Sue is a 1941 American Western film directed by William Morgan and starring Gene Autry, Smiley Burnette, and Fay McKenzie. Written by Earl Felton and Julian Zimet, the film is about a government inspector investigating a poisonous weed that is destroying the rangeland supporting the area's cattle. The inspector must persuade the ranchers to reject a plan to burn the land and support a new process of chemical spraying from an airplane. The film features the popular Autry songs "Be Honest With Me", "Ridin' the Range", and the title track.

Lester Alvin Burnett, better known as Smiley Burnette, was an American country music performer and a comedic actor in Western films and on radio and TV, playing sidekick to Gene Autry, Roy Rogers, and other B-movie cowboys. He was also a prolific singer-songwriter who is reported to have played proficiently over 100 musical instruments, sometimes more than one simultaneously. His career, beginning in 1934, spanned four decades, including a regular role on CBS-TV's Petticoat Junction in the 1960s.