Simcoe is an unincorporated community and former town in Southwestern Ontario, Canada near Lake Erie. It is the county seat and largest community of Norfolk County. Simcoe is at the junction of Highway 3, at Highway 24, due south of Brantford, and accessible to Hamilton by nearby Highway 6. The largest of the communities in Norfolk County, Simcoe had a population of 16,121 at the time of the 2021 Census.

King's Highway 6, commonly referred to as Highway 6, is a provincially maintained highway in the Canadian province of Ontario. It crosses a distance of 480 km (300 mi) between Port Dover, on the northern shore of Lake Erie, and Espanola, on the northern shore of Lake Huron, before ending at the Trans-Canada Highway (Highway 17) in McKerrow.