Simplicius of Cilicia was a disciple of Ammonius Hermiae and Damascius, and was one of the last of the Neoplatonists. He was among the pagan philosophers persecuted by Justinian in the early 6th century, and was forced for a time to seek refuge in the Persian court, before being allowed back into the empire. He wrote extensively on the works of Aristotle. Although his writings are all commentaries on Aristotle and other authors, rather than original compositions, his intelligent and prodigious learning makes him the last great philosopher of pagan antiquity. His works have preserved much information about earlier philosophers which would have otherwise been lost.

Empedocles was a Greek pre-Socratic philosopher and a native citizen of Akragas, a Greek city in Sicily. Empedocles' philosophy is best known for originating the cosmogonic theory of the four classical elements. He also proposed forces he called Love and Strife which would mix and separate the elements, respectively.