Sir John Wedderburn, 5th Baronet of Blackness, was a Perthshire gentleman who joined the 1745 rebellion of Charles Edward Stuart. He was captured at the Battle of Culloden, taken to London, and convicted of treason. He was hanged, his estates were forfeit to the Crown, and his family was attainted. The Blackness in his title is Blackness House in Dundee rather than Blackness in Lothian just west of Edinburgh. His son John Wedderburn of Ballindean fled after his father's death to Jamaica, where he re-established the family's fortunes via slave sugar, and eventually regained his father's title.

Sir John Wedderburn of Ballindean, 6th Baronet of Blackness (1729–1803) was a Scottish landowner who made a fortune in slave sugar in the West Indies. Born into a family of impoverished Perthshire gentry, his father, Sir John Wedderburn, 5th Baronet of Blackness, was executed for treason following the Jacobite uprising of 1745, and the young Wedderburn was forced to flee to the West Indies, where he eventually became the largest landowner in Jamaica. In 1769 he returned to Scotland with a slave, one Joseph Knight, who was inspired by Somersett's Case, a judgment in London determining that slavery did not exist under English law. Wedderburn was sued by Knight in a freedom suit, and lost his case, establishing the principle that Scots law would not uphold the institution of slavery either. Wedderburn ended his days as a wealthy country gentleman, having restored his family fortune and recovered the title Baronet of Blackness.