Sir Thomas Gascoigne, 2nd Baronet (1596–1686) was an English Baronet, a prominent member of the Gascoigne family and a survivor of the Popish Plot, or as it was locally known "the Barnbow Plot".

The Gascoigne Baronetcy, of Barnbow and Parlington in the County of York, was a title in the Baronetage of Nova Scotia. It was created on 8 June 1635 for John Gascoigne. He had converted to Roman Catholicism in 1604. His daughter, Catherine Gascoigne, went to Cambrai where she became an abbess. Gascoigne's son Sir Thomas, 2nd Baronet, was accused of conspiracy to murder King Charles II as part of the mythical Popish Plot, but acquitted. The eighth Baronet was Member of Parliament for Thirsk, Malton and Arundel. He renounced Catholicism, and was much involved in the Irish Parliament and in horse racing. Sir Thomas died in 1810, the year after his only son died in a hunting accident, upon which the baronetcy became either extinct or dormant.