Sisaket province is one of Thailand's seventy-six provinces (changwat). It lies in lower northeastern Thailand, a region called Isan. Neighboring provinces are : Surin, Roi Et, Yasothon, and Ubon Ratchathani. To the south it borders Oddar Meancheay and Preah Vihear of Cambodia.

The provinces of Thailand are administrative divisions of the government of Thailand. The country is divided into 76 provinces proper, with one additional special administrative area. They are the primary local government units and act as juristic persons. They are divided into amphoe (districts) which are further divided into tambon, the next lower level of local government.