Sister Irene was an American nun who founded the New York Foundling Hospital in 1869, at a time when abandoned infants were routinely sent to almshouses with the sick and insane. The first refuge was in a brownstone on E.12th St. in Manhattan, where babies could be left anonymously in a receiving crib with no questions asked. The practice was an echo of the medieval foundling wheel and an early example of modern "safe haven" practices.

The New York Foundling, founded in 1869 by the Roman Catholic Sisters of Charity, is one of New York City's oldest and largest child welfare agencies. The Foundling operates programs in the five boroughs of New York City, Rockland County, and Puerto Rico. Its services include foster care, adoptions, educational programs, mental health services, and many other community-based services for children, families, and adults.