Sisters is a city in Deschutes County, Oregon, United States. It is part of the Bend, Oregon Metropolitan Statistical Area. The population was 2,038 at the 2010 census.

Deschutes County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 198,253. The county seat is Bend. The county was created in 1916 out of part of Crook County and was named for the Deschutes River, which itself was named by French-Canadian trappers of the early 19th century. It is the political and economic hub of Central Oregon. Deschutes comprises the Bend, Oregon Metropolitan Statistical Area and media market. Deschutes is Oregon's fastest-growing and most recently formed county.