The Skleros, latinized Sclerus, feminine form Skleraina (Σκλήραινα), Latinized Scleraena, was a noble Byzantine family active mostly in the 9th–11th centuries as members of the military aristocracy, and as civil functionaries thereafter.

Bardas Skleros or Sclerus was a Byzantine general who led a wide-scale Asian rebellion against Emperor Basil II during the years 976 to 979.