Skyline is a town in Jackson County, Alabama, United States. The town incorporated in 1985. As of the 2010 census, the population of the town was 851, up from 843 in 2000.

Jackson County is the northeasternmost county in the U.S. state of Alabama. As of the 2020 census, the population was 52,579. The county seat is Scottsboro. The county was named for Andrew Jackson, general in the United States Army and afterward President of the United States of America. Jackson County is a prohibition or dry county, but three cities within the county are "wet", allowing alcohol sales. Jackson County comprises the Scottsboro, AL Micropolitan Statistical Area, and Jackson county is included in the Scottsboro-Fort Payne combined statistical areas. It is the site of Russell Cave National Monument, an archeological site with evidence of 8,000 years of human occupation in the Southeast.