Skyline Chili is a chain of Cincinnati-style chili restaurants based in Cincinnati, Ohio. Founded in 1949 by Greek immigrant Nicholas Lambrinides, Skyline Chili is named for the view of Cincinnati's skyline that Lambrinides could see from the first restaurant, opened in the section of town now known as Price Hill. It is also the "official chili" of many local professional sports teams and venues, including the Cincinnati Bengals, Cincinnati Reds, Cincinnati Cyclones, Columbus Blue Jackets and the Kings Island theme park, and also sponsors the Crosstown Shootout, an annual men's college basketball rivalry game between the city's two NCAA Division I teams, Cincinnati and Xavier.

Cincinnati chili is a Mediterranean-spiced meat sauce used as a topping for spaghetti or hot dogs ("coneys"); both dishes were developed by immigrant restaurateurs in the 1920s. Its name evokes comparison to chili con carne, but the two are dissimilar in consistency, flavor, and serving method; Cincinnati chili more closely resembles Greek pasta sauces and spiced-meat hot dog topping sauces seen in other parts of the United States.