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Slane

Slane is a village in County Meath, in Ireland. The village stands on a steep hillside on the left bank of the River Boyne at the intersection of the N2 and the N51; as of the 2016 census, Slane's population was 1,369. The village and surrounding area contains many historic sites dating back over 5,000 years; the village centre, as it is laid-out today, dates from the 18th century. While the area and its surroundings have been inhabited since at least the Neolithic era and with literature references upon the introduction of Christianity and the hill of Slane settlement, as discussed in the stolen 1092 Annals of Inisfallen; the earliest surviving structures, in what is considered the boundaries of the modern day village, were built by the invading Norman family of the Flanders, during the Norman invasion of Ireland. The most undisturbed structure, built under the feudal lordship of this family is a Motte and Bailey, in close proximity to the hill of Slane settlement. Following the Williamite confiscations, which saw the Flemings dispossessed, the present form of the Castle and the village centre were re-cast and in the latter case, laid out as a model British village by the Ulster plantation family of the Conynghams, in what is considered a typical example of 18th-century town planning.

As part of this remodelling, today in the centre of the village stand four nearly identical Georgian houses. The four houses stand at the intersection of the two main streets in the village. While the four faces of the houses and the four open streets form an octagon; the feature is known as The Square due to what is seen as the vertex position, that each house occupies. The South-Western-most house that forms the square, served as the Royal Irish Constabulary barracks and gaol, up until the founding of the Irish State; the two main streets in the village feature 18th century grey limestone buildings with slate roofs, oriel windows and archways. The village centre incorporates "Gallows hill", the foot of, the location of the present day "Slane Credit Union" and a hill so named for the United Irishmen who were publicly executed there on a gallows in an attempt to deter further agitations for independence, following the failed 1798 uprising. In 2007 Meath County Council proposed that both Slane village and the mill be recognised as Architectural Conservation Areas and protected according.

In the 20 years between the 1996 and 2016 census, Slane doubled in population, from 699 to 1,369 inhabitants. As of the 2006 census, there were 1,099 people living in Slane, having grown from a population of 823 in 2002; the population of the village and the surrounding rural area was 1,587 in 2006, up from 1,336 in 2002. According to the 2016 census, of those who commute to work or school, 77% had a commute of less than 1 hour; the earliest recorded inter-county match of caid, equivalent to modern Gaelic football, in the entirety of Ireland. The modern day Slane Gaelic Football Club comprises the local parish Gaelic Athletic Association Gaelic football teams for the urban and rural areas of Slane. Teams play their home games in Toddy Harding Park, located 5 kilometres north of the village. Slane Wanderers is the village's local football club, whose home games are played in Wheatfield Park. In 1979, the inaugural Irish Motocross Grand Prix was held in Slane. To the north of the village rises the Hill of Slane, which stands 158 metres above the surroundings.

There are a number of historic sites located around the top of the hill. In the Metrical Dindshenchas, a collection of bardic verse, the ancient Fir Bolg king Sláine mac Dela was said to have been buried here, in the place, called Druim Fuar that came to be known in his memory Dumha Sláine. There is an artificial mound on the western end of the hilltop; the hill may have been chosen as the site of Christian abbey due to the presence of an existing pagan shrine, the remains of which may be two standing stones in the burial yard. Muirchu moccu Machtheni, in his mythologised seventh century Life of Patrick, says that St. Patrick lit a Paschal fire on this hill top in A. D. 433 in defiance of the High King Laoire who forbid any other fires while a festival fire was burning on the Hill of Tara. Historians and archaeologists agree. According to Muirchu, Logaire was so impressed by Patrick's devotion that, despite his defiance, he let him continue his missionary work in Ireland, it is somewhat more certain that Patrick appointed a bishop of Saint Erc.

The Hill of Slane remained a centre of learning for many centuries after St. Patrick; the ruins of a friary church and college can be seen on the top of the hill. It is known that Slane Friary was restored in 1512; the ruins include a 19-metre high early gothic tower. The friary was abandoned in 1723; the traditional Christian hymn Be Thou My Vision is set to an early medieval Irish folk song named Slane, about the Hill of Slane. 150 meters west of the college and friary church, hidden by trees, lay the steeply inclined remains of a twelfth-century Norman motte and bailey, built by Richard Fleming in the 1170s. This was the seat of the Flemings of barons of Slane; the Flemings moved to a castle on the left bank of the River Boyne, the current location of Slane Castle. The Flemings were lords of Slane from the twel

Heme oxygenase

Heme oxygenase or haem oxygenase is an enzyme that catalyzes the degradation of heme. This produces biliverdin, ferrous iron, carbon monoxide. HO was first described in the late 1960's when Raimo Tenhunen demonstrated an enzymatic reaction for heme catabolism. HO is the premier source for endogenous carbon monoxide production. Indeed, monitored small doses of CO are being studied for therapeutic benefits. Heme oxygenase is a heme-containing member of the heat shock protein family identified as HSP32. HO-1 is a 32kDa enzyme. HO is located in the endoplasmic reticulum, though it has been reported in the mitochondria, cell nucleus, plasma membrane. HO catalyzes the degradation of heme to biliverdin/bilirubin, ferrous iron, carbon monoxide. Though present throughout the body, HO has significant activity in the spleen in the degradation of hemoglobin during erythrocyte recycling, which accounts for ~80% of the heme derived endogenous CO production; the remaining 20% of heme derived CO production is attributed to hepatic catabolism of hemoproteins and ineffective erythropoiesis in bone marrow.

HO enzymes are degraded via ubiquitination. In humans three isoforms of heme oxygenase are known. Heme oxygenase 1 is a stress-induced isoform present throughout the body with highest concentrations in the spleen and kidneys. HO-1 is a 32kDa enzyme containing 288 amino acid residues, encoded by the HMOX1 gene. A study has found levels of HO-1 in lung tissue were directly related to infection with Tuberculosis or infection-free areas, knockout mice were found susceptible, showing the essential role of this enzyme. Heme oxygenase 2 is a constitutive isoform, expressed under homeostatic conditions in the testes, endothelial cells and the brain. HO-2 is encoded by the HMOX2 gene. HO-2 is shares 47 % similarity with the HO-1 amino acid sequence. A third heme oxygenase is considered to be catalytically inactive and is thought to work in heme sensing or heme binding. HO-3 is 33 kDa with greatest presence in the liver and kidneys. Heme oxygenase is conserved across phylogenic kingdoms; the European Bioinformatics Institute’s InterPro taxonomy database indicates there are 4,347 bacteria species, 552 fungi species, 6 archaea species expressing a HO-1-like enzymes.

Microbial HO homologues use different abbreviation such as HMX1 in Saccharomyces cerevisiae, Hmu O in Corynebacterium diphtheriae, Chu S in Escherichia coli. A critical role of the prokaryotic HO systems is to facilitate acquisition of nutritional iron from a eukaryotic host; some HO-like prokaryotic enzymes are inactive or do not liberate CO. Certain strains of Escherichia coli express the non-CO producing Chu W isoform, whilst HO-like enzymes in other microbes have been reported to produce formaldehyde; the human microbiome contributes to endogenous carbon monoxide production in humans. Heme oxygenase cleaves the heme ring at the alpha-methene bridge to form either biliverdin or, if the heme is still attached to a globin, verdoglobin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase; the reaction comprises three steps, which may be: Heme b3+ + O2 + NADPH + H+→ α-meso-hydroxyheme3+ + NADP++ H2O α-meso-hydroxyheme3+ + H++ O2 → verdoheme4+ + CO + H2O verdoheme4+ + 7/2 NADPH + O2+ 3/2 H+ → biliverdin + Fe2+ + 7/2 NADP++ H2OThe sum of these reactions is: Heme b3+ + 3O2 + 9/2 NADPH + 7/2 H+ → biliverdin + Fe2+ + CO + 9/2 NADP++ 3H2OIf the iron is in the +2 state, the reaction could be: Heme b2+ + 3O2 + 4 NADPH + 4 H+ → biliverdin + Fe2+ + CO + 4 NADP+ + 3H2O This reaction can occur in every cell.

In terms of molecular mechanisms, the enzyme facilitates the intramolecular hydroxylation of one meso carbon centre in the heme. HO-1 is induced by countless molecules including heavy metals, paclitaxel, probucol, nitric oxide, carbon monoxide, carbon monoxide-releasing molecules, porphyrins. Phytochemical inducers of HO include: curcumin, piceatannol, caffeic acid phenethyl ester, dimethyl fumarate, fumaric acid esters, chalcones, ginkgo biloba, phlorotannins, rosolic acid, numerous other natural products. Endogenous inducers include i) lipids such as lipoxin and epoxyeicosatrienoic acid. NRF2 inducers with downstream HO-1 induction include: genistein, 3-hydroxycoumarin, oleanolic acid, isoliquiritigenin, PEITC, diallyl trisulfide, benfotiamine, acetaminophen, paraquat, diesel exhaust particles, nanotubes, 15‐deoxy‐Δ12,14 prostaglandin J2, nitro-oleic acid, hydrogen peroxide, succinylacetone. Heme oxygenase expression is induced by oxidative stress, in animal models increasing this expression seems to be protective.

Carbon monoxide released from heme oxygenase reactions can influence vascular tone independently or influence the function of nitric oxide synthase. See also: carbon monoxide-releasing moleculesThe first detection of CO in humans was in 1949. Sjöstrand determined that CO originated from the alpha-methene carbon of heme, setting the stage for the molar ratio between hemin degradation and CO production to be established. HO is the main source of endogenous CO production, though other minor contributors have been identified in recent years. CO is formed at a rate of 16.4 µmol/hour in the human body, ~86% originating from heme via heme oxygenase

Glintshake

Glintshake is a Russian rock band formed in Moscow in 2012. The group is composed of vocalist and guitarist Ekaterina Shilonosova, guitarist Yevgeni Gorbunov, bassist Yegor Sargsyan, drummer Alexey Yevlanov; the founders of the band, Ekaterina Shilonosova and Yevgeni Gorbunov, met in Kazan. In 2011, Shilonosova moved to Moscow. Glintshake's debut EP, Freaky Man, was recorded by Shilonosova and Gorbunov and published to the web in June 2012. In October, they released a music video for the title track, "Freaky Man", starring artist Alexander Krivoshapkin; the bassist Dmitry Midborn and drummer Vasily Nikitin joined the band in October 2012. Each member had had experience in other music projects: Shilonosova in MAKE and NV, Gorbunov in NRKTK and Stoned Boys, Midborn in Tesla Boy and On-The-Go, Nikitin in Foojitsu; the first gig took place in Kazan on November 17, 2012. In March 2013, Glintshake released their second EP, after which they were invited to several major festivals in Moscow: Bosco Fresh Fest, Afisha Picnic, Faces & Laces.

In August 2013, the band opened for The Smashing Pumpkins at Stadium Live in Moscow. In the autumn of 2013, bassist Dmitry Midborn left Glintshake and was replaced by Yegor Sargsyan from the band Trud. At the beginning of 2014, drummer Vasily Nikitin was replaced by Alexey Yevlanov from The Twiggys. In May 2014, the band released their debut album Eyebones. In May 2014, Glintshake released a video for the song "Wiuwiuwiu", filmed on iPhone and edited in a single day. In November, they released an EP, Nano Banana, recorded in a new studio near Moscow owned by Xuman Records label. According to Yevgeni Gorbunov, the EP was "free in terms of style", due to the band moving away from their 90s music influence. At the end of 2014, Glintshake recorded the song "New Year of Hate" for Afisha's New Year's project. Early in 2015, Glintshake re-recorded the song "Mu" from the Nano Banana EP in Russian. According to Shilonosova, the original English text had little overlap with the Russian lyrics, but its meaning and general atmosphere were not changed.

The re-recorded version of "Мu" and "New Year of Hate" were released on the deluxe version of Nano Banana in June. In September, a music video for the song "Wrong Anthem" was released, created by illustrator Alexander Kostenko. At the same time, the band announced, that "good old Glintshake is coming to an end, but new and evil one is starting off". In an interview with the website FURFUR, Yevgeni Gorbunov said that the band had decided to withdraw from 90s alternative rock influence, stop singing in English, make a full turn in work: "…We've got a whole bunch of our own stuff: Zvuki Mu, russian avant-garde." In October, Glintshake released a single from their upcoming album, the song "Без пятнадцати пять" along with a music video. In November, they released "Тени". In 2016, the band released an album of songs in Russian called ОЭЩ МАГЗИУ—a cryptic acronym in Russian, which can be pronounced as OESCH MAGZIU. In 2018, Glintshake's cover of the Talking Heads song "Psycho Killer" was featured in the film Leto.

2014 – Eyebones 2016 – ОЭЩ МАГЗИУ 2018 – Польза 2012 – Freaky Man 2013 – Evil 2014 – Dive 2014 – Nano Banana Glintshake on SoundCloud Glintshake on Last.fm Glintshake on Bandcamp Glintshake on Facebook

Moon Soon-ho

Moon Soon-Ho is a South Korean football player who plays for Woodlands Wellington FC in the S-League. Having finished last in the 2007 S-League season, Super Reds FC made several changes to their squad and Moon, along with his Incheon Korail team-mate Choi Young-Min, were signed up from the Korea National League side for the 2008 S-League season. Moon scored a total of seven goals during that season, netting crucial match winning goals against Gombak United and Courts Young Lions. In 2009, Moon decided to move back to his native South Korea to join Korea National League side Cheonan City FC. With a knee injury hampering him during his time back in the Korea National League, Moon had little playing time at Cheonan. However, he managed to score 2 goals during his maiden season in 2009 despite spending most of his time on the sidelines, he was deployed as a substitute. He finish his season with 2 goals in 6 appearance for the club. In his second season with Cheonan, Moon did make an impact by coming off the bench to score a stunner for Cheonan against Yongin City FC on 30 April 2010.

His knack for scoring goals when coming on as a substitute earned him the title "super-sub". At the end of the 2010 Korea National League season, despite scoring 3 goals in 10 appearances, Moon was released by the club as he struggled to recover from his injury. Moon would soon return to the S. League when he was snapped up by Woodlands Wellington FC during the 2011 mid-season transfer window as a free agent. Joining him at the club was fellow Korean Hyun Jong-Woon, whom switched to the Rams from Tanjong Pagar United. Moon proved to be a shrewd signing for Woodlands, as he scored 8 goals in the latter half of the season and finished the 2011 season as Woodlands' top scorer. Moon kick-started the 2012 S-League season in great fashion, earning a penalty against the favoured Courts Young Lions and calmly slotting it home in the 48th minute, putting the Rams into the lead and winning the game for them. Moon's telepathic understanding with Lebanese Australian attacking midfielder Hussein Akil has been praised by football pundits, despite the pair only playing together at the start of the 2012 season.

Moon finished as Woodlands Wellington's top scorer for the Rams' 2012 S. League season with 9 goals in the S-League and 1 goal in the Singapore Cup, which he scored against Kanbawza FC. In the 2013 S. League season, Moon finished as joint-top scorer in the S. League with 15 league goals and built up a telepathic relationship with fellow Korean striker Jang Jo-Yoon as the Rams stormed to a top-six finish. Moon's fantastic performances earned him a spot in the inaugural Goal.com Singapore Football Awards' Team of the Year. As of 16 July 2013Moon Soon-Ho's Profile All numbers encased in brackets signify substitute appearances

Willie Geist

William Russell Geist is an American television personality and humorist. He is anchor of Sunday Today with Willie Geist. Geist frequently serves as a fill-in anchor on both the weekday edition and the Saturday edition of Today. Geist is a correspondent for NBC News and NBC Sports and contributing to NBC's Olympic coverage. Geist is the author or co-author of two humor books that have appeared on The New York Times bestseller list: Good Talk, Dad – written in 2014 with his father Bill Geist – and American Freak Show: The Completely Fabricated Stories of Our New National Treasures, released on October 12, 2010, his third book, the self-help satire Loaded! Become a Millionaire Overnight and Lose 20 Pounds in 2 Weeks or Your Money Back! Released on May 10, 2011. Geist was born in Evanston, the son of broadcast journalist Bill Geist and mother Jody Geist. Geist is the older brother of a documentary film producer, he is the great-grandson of Hockey Hall of Fame hockey player Herbie Lewis. Geist attended George Washington Middle School in Ridgewood, New Jersey, where he began dating his future wife, Christina Sharkey.

He attended Ridgewood High School, where he played basketball and was the quarterback on the football team. He attended Vanderbilt University. Geist began his career as an editor and producer for CNN Sports Illustrated and subsequently a field producer and reporter for CNN Sports, where he covered the Super Bowl, the NCAA Final Four, The Masters. Geist began substituting as a co-host on MSNBC's 6–9 a.m. morning time slot immediately after Don Imus was fired in late April 2007. Geist was named permanent co-host of Morning Joe, along with Joe Scarborough and Mika Brzezinski in September 2007. In late July 2009, Geist began hosting his own 30-minute program Way Too Early with Willie Geist, which airs at 5:30 a.m. before Morning Joe on MSNBC. In 2010, Geist began substituting for Matt Lauer as host of the Today Show and as the show's newsreader. In November 2012, Geist left Way Too Early. In 2016, Geist was made solo-host of the new Sunday Today. Additionally Geist contributed to NBC Sports and NBC News's coverage of the 2014 Winter Olympic Games.

Geist anchored NBC's hours-long coverage of the 2016 Orlando nightclub shooting on the morning of June 12, 2016. Geist was on the air for seven successive hours in an NBC News Special Report that aired across the United States. Willie Geist did voice work in Kung Fu Panda 3 where he voiced Sum opposite of Al Roker's Dim where their characters are twin panda brothers who are related to Po. On May 24, 2003, Geist married his middle-school sweetheart Christina Sharkey, in Humacao, Puerto Rico; the couple has a daughter, Lucie Joy, a son, George William. He is an Independent.: I, Writer/Producer MSNBC/NBC News/NBC Sports: Tucker: Zeitgeist Host: Scarborough Country: Morning Joe Co-Anchor: Way Too Early Host: NBC News correspondent: NBC Sports contributor: Today Show Third Hour Co-Anchor: Today Show 7–9 am contributor and fill-in news, Orange Room and co-anchor: Sunday Today with Willie Geist-Anchor Willie Geist on IMDb Works by or about Willie Geist in libraries Appearances on C-SPAN 2009 Miss USA judge official biography

WPIA

WPIA is a radio station licensed to Eureka and serving the greater Peoria and Bloomington, areas. The station is owned and operated by Advanced Media Partners, LLC; the station went on the air as WCRI in 1989 with an easy listening format. It was owned by Inc.. WCRI programmed local news, farm news including grain and livestock prices, high school and Eureka College sports as well as a blend of 1940s, 1950s, 1960s music. Local librarians created and hosted a weekly five-minute program "Queries and Quotes." The daily talk show "Woodford County Today" focused on area events. Students from the local grade school read the daily lunch menu; the station operated at 3,000 watts. The studios were at 103 North Major, across the street from the courthouse to the west and Eureka Hospital to the south; the station was sold in 1994 to the owner of WPOK/Pontiac, his business partners, became WIVR with an adult contemporary format. After three years as WIVR, "98.5 The River," the station was bought by the owners of WEEK-TV in 1996, who would turn it into "Oldies 98.5" with the callsign WEEK-FM the following year, the only radio station owned by Granite Broadcasting.

After 93.3 became WPBG, putting it in direct competition with WEEK-FM, 98.5's ratings slid and Granite sold the radio station. In March 1998, WEEK-FM flipped to Hot AC. Beginning in August 1999, the station was called WPPY, "98.5 The Party", with a Top 40/CHR format. In August 2000, WPPY added a simulcast on 101.1 WRVP swapping callsigns with 101.1 to become WRVP itself. In March 2004, the simulcast with WPPY was broken, as WRVP's call letters were changed to WPIA and flipped to Christian rock as "Hope 98.5." In September 2006, then-owners Regent Communications sold the station and 101.1 FM to Independence Media Holdings, who bought 96.5 WHPI from another company and returned the Top 40/CHR format to 98.5, but this time adding a simulcast with the latter frequencey to form "96.5 & 98.5 KISS FM". On July 1, 2007, 98.5 stopped simulcasting 96.5. Independence Media Holdings sold WPIA, along with its other three Peoria-area stations to Advanced Media Partners on November 15, 2010. KISS FM Peoria — official website Query the FCC's FM station database for WPIA Radio-Locator information on WPIA Query Nielsen Audio's FM station database for WPIA