The legal institution of human chattel slavery, comprising the enslavement primarily of Africans and African Americans, was prevalent in the United States of America from its founding in 1776 until 1865, predominantly in the South. Slavery was established throughout European colonization in the Americas. From 1526, during the early colonial period, it was practiced in what became Britain's colonies, including the Thirteen Colonies that formed the United States. Under the law, an enslaved person was treated as property that could be bought, sold, or given away. Slavery lasted in about half of U.S. states until abolition in 1865, and issues concerning slavery seeped into every aspect of national politics, economics, and social custom. In the decades after the end of Reconstruction in 1877, many of slavery's economic and social functions were continued through segregation, sharecropping, and convict leasing.

African Americans, also known as Black Americans or Afro-Americans, are an ethnic group consisting of Americans with partial or total ancestry from any of the Black racial groups of Africa. African Americans constitute the third largest racial or ethnic group in the U.S. after White Americans and Hispanic and Latino Americans. The term "African American" generally denotes descendants of Africans enslaved in the United States.