The Smestow Brook, sometimes called the River Smestow, is a small river that plays an important part in the drainage of Wolverhampton, South Staffordshire, and parts of Dudley in the United Kingdom, and has contributed to the industrial development of the Black Country. It is the most important tributary of the River Stour, Worcestershire and part of the River Severn catchment.

Wolverhampton is a city and metropolitan borough in the West Midlands, England. Located 12 miles (19 km) northwest of Birmingham, the population in 2021 was 263,700.