Smisby is an ancient manor, civil parish and small village in South Derbyshire, England.
It is 4 miles (6.4 km) from Melbourne and near the Leicestershire border and the town of Ashby-de-la-Zouch. The village including the outlying farms and houses has a population just over 200 that occupies some 110 properties. The population at the 2011 Census had increased to 260.
Smisby's church of St. James. The church was originally dedicated to Saint Wystan of Repton and is mentioned in a charter of 1271.