Smithers is a city in Fayette and Kanawha counties in the U.S. state of West Virginia. Located along the Kanawha River, it lies almost entirely in Fayette County. The population was 751 at the 2020 census. The city most likely takes its name from Smithers Creek. The small river city is noted for having a rich cultural history related to both its coal mining and Italian-American heritages.

Fayette County is a county in the U.S. state of West Virginia. As of the 2020 census, the population was 40,488. Its county seat is Fayetteville. It is part of the Beckley, WV Metropolitan Statistical Area in Southern West Virginia.