Smiths Station is a city in Lee County, Alabama, United States. It is part of the Columbus, Georgia metropolitan area. At the time of the 2000 census, it was still a census-designated place (CDP), and its population was 6,756. The area that incorporated as Smiths Station in 2001 was much smaller than the CDP, and contained a population of 4,926 by the 2010 census. Smiths Station, known to locals as "Smiths", is a bedroom community of Columbus, Georgia, and Phenix City, Alabama. Smiths Station High School has an enrollment of over 1,800 students and is the 11th-largest high school in the state.

Lee County is a county located in east central Alabama. As of the 2020 census the population was 174,241. The county seat is Opelika, and the largest city is Auburn. The county was established in 1866 and is named for General Robert E. Lee (1807–1870), who served as General in Chief of the Armies of the Confederate States in 1865. Lee County comprises the Auburn-Opelika, AL Metropolitan Statistical Area, which is included in the Columbus-Auburn-Opelika, GA-AL Combined Statistical Area.