Snake handling, also called serpent handling, is a religious rite observed in a small number of isolated churches, mostly in the United States, usually characterized as rural and part of the Holiness movement. The practice began in the early 20th century in Appalachia and plays only a small part in the church service. Participants are Holiness, or Pentecostals. The beliefs and practices of the movement have been documented in several films and have been the impetus for a number of state laws related to the handling of venomous animals.

Mark 16 is the final chapter of the Gospel of Mark in the New Testament of the Christian Bible. Christopher Tuckett refers to it as a "sequel to the story of Jesus' death and burial". The chapter begins after the sabbath has ended, with Mary Magdalene, Mary the mother of James, and Salome purchasing spices to bring to the tomb next morning to anoint Jesus' body. There they encounter the stone rolled away, the tomb open, and a young man dressed in white who announces the resurrection of Jesus. The two oldest manuscripts of Mark 16 conclude with verse 8, which ends with the women fleeing from the empty tomb, and saying "nothing to anyone, because they were too frightened".