Sofonisba Anguissola, also known as Sophonisba Angussola or Sophonisba Anguisciola, was an Italian Renaissance painter born in Cremona to a relatively poor noble family. She received a well-rounded education that included the fine arts, and her apprenticeship with local painters set a precedent for women to be accepted as students of art. As a young woman, Anguissola traveled to Rome where she was introduced to Michelangelo, who immediately recognized her talent, and to Milan, where she painted the Duke of Alba. The Spanish queen, Elizabeth of Valois, was a keen amateur painter and in 1559 Anguissola was recruited to go to Madrid as her tutor, with the rank of lady-in-waiting. She later became an official court painter to the king, Philip II, and adapted her style to the more formal requirements of official portraits for the Spanish court. After the queen's death, Philip helped arrange an aristocratic marriage for her. She moved to Sicily, and later Pisa and Genoa, where she continued to practice as a leading portrait painter.

Cremona is a city and comune in northern Italy, situated in Lombardy, on the left bank of the Po river in the middle of the Pianura Padana. It is the capital of the province of Cremona and the seat of the local city and province governments. The city of Cremona is especially noted for its musical history and traditions, including some of the earliest and most renowned luthiers, such as Giuseppe Guarneri, Antonio Stradivari, Francesco Rugeri, Vincenzo Rugeri, and several members of the Amati family.