Something's Got to Give is an unfinished American feature film shot in 1962, directed by George Cukor for 20th Century Fox and starring Marilyn Monroe, Dean Martin and Cyd Charisse. A remake of My Favorite Wife (1940), a screwball comedy starring Irene Dunne and Cary Grant, it was Monroe's last work, but from the beginning of its production it was disrupted by her personal troubles, and after her death on August 4, 1962, the film was abandoned. Most of its completed footage remained unseen for many years.

My Favorite Wife, released in the United Kingdom as My Favourite Wife, is a 1940 screwball comedy produced by Leo McCarey and directed by Garson Kanin.