Soong Mei-ling, also known as Madame Chiang Kai-shek or Madame Chiang, was a Chinese political figure who was First Lady of the Republic of China, the wife of President Chiang Kai-shek of the Republic of China. Soong played a prominent role in the politics of the Republic of China and was the sister-in-law of Sun Yat-sen, the founder and the leader of the Republic of China. She was active in the civic life of her country and held many honorary and active positions, including chairwoman of Fu Jen Catholic University. During World War II, she rallied against the Japanese; and in 1943 conducted an eight-month speaking tour of the United States to gain support.

The First Lady of the Republic of China refers to the wife of the President of the Republic of China. Since 1949, the position has been based in Taiwan, where they are often called by the title of First Lady of Taiwan, in addition to First Lady of the Republic of China (ROC).