Sophia Petrillo is a character from the sitcom television series The Golden Girls and its spin-offs The Golden Palace and Empty Nest. She also appeared in episodes of the series Blossom and Nurses. Her character was played by the actress Estelle Getty for 10 years and 258 episodes.

The Golden Girls is an American sitcom created by Susan Harris that aired on NBC from September 14, 1985, to May 9, 1992, with a total of 180 half-hour episodes, spanning seven seasons. With an ensemble cast starring Bea Arthur, Betty White, Rue McClanahan, and Estelle Getty, the show is about four older women who share a home in Miami, Florida. It was produced by Witt/Thomas/Harris Productions, in association with Touchstone Television. Paul Junger Witt, Tony Thomas, and Harris served as the original executive producers.