South Arkansas lies within the southernmost portions of Arkansas Gulf Coastal Plain and Delta regions. It encompasses the lower 15 counties of the state.

Ashley County is a rural South Arkansas county with a culture, economy, and history based on timber and agriculture. Created as Arkansas's 52nd county on November 30, 1848, Ashley County has seven incorporated municipalities, including Hamburg, the county seat and Crossett, the most populous city. The county is also the site of numerous unincorporated communities and ghost towns. The county is named for Chester Ashley, a prominent lawyer in the Arkansas Territory and U.S. senator from the state from 1844 to 1848.