South Ayrshire was a county constituency of the House of Commons of the Parliament of the United Kingdom from 1868 until 1983, when it was abolished. It returned one Member of Parliament (MP), elected by the first past the post voting system.

Ayrshire is a historic county and registration county, in south-west Scotland, located on the shores of the Firth of Clyde. The lieutenancy area of Ayrshire and Arran covers the entirety of the historic county as well as the island of Arran, formerly part of the historic county of Buteshire. Its principal towns include Ayr, Kilmarnock and Irvine and it borders the counties of Renfrewshire and Lanarkshire to the north-east, Dumfriesshire to the south-east, and Kirkcudbrightshire and Wigtownshire to the south. Like many other counties of Scotland, it currently has no administrative function, instead being sub-divided into the council areas of East Ayrshire, North Ayrshire and South Ayrshire. It has a population of approximately 366,800.