South Buffalo is a neighborhood that makes up the southern third of the City of Buffalo, New York. Traditionally known for its large Irish-American community, this community also has a strong presence of various other nationalities. The once-heavily industrialized district was home to many steel mills, automotive parts manufacturers, petroleum refineries, foundries, and machine shops. However, due to increasing deindustrialization and rising unemployment, the area has experienced growing problems with poverty and population decline.

Patrick B. Burke is an American politician who serves in the New York State Assembly from the 142nd district, which represents South Buffalo, the City of Lackawanna, and the towns of West Seneca and Orchard Park. Burke is a South Buffalo native.