South Carolina's 6th congressional district is in central and eastern South Carolina. It includes all of Allendale, Bamberg, Calhoun, Clarendon, Hampton, and Williamsburg counties and parts of Charleston, Colleton, Dorchester, Florence, Jasper, Orangeburg, Richland and Sumter counties. With a Cook Partisan Voting Index rating of D+14, it is the only Democratic district in South Carolina.

Allendale County is a county located in the U.S. state of South Carolina. As of the 2020 census, the population was 8,039, making it the least populous county in South Carolina. Its county seat is Allendale.