South Carolina Highway 61 (SC 61) is a 67-mile-long (108 km) state highway in the U.S. state of South Carolina. The highway is designated on a north–south direction, but physically travels in an east–west direction, from SC 30 in Charleston to U.S. Route 78 (US 78) near Branchville. The portion of SC 61 from Church Creek Bridge and 10 miles (16 km) north is designated a National Scenic Byway.

A National Scenic Byway is a road recognized by the United States Department of Transportation for one or more of six "intrinsic qualities": archeological, cultural, historic, natural, recreational, and scenic. The program was established by Congress in 1991 to preserve and protect the nation's scenic but often less-traveled roads and promote tourism and economic development. The National Scenic Byways Program (NSBP) is administered by the Federal Highway Administration (FHWA).