The South Carolina State Museum is a museum dedicated to the history of South Carolina. It has four floors of permanent and changing exhibits, a digital dome planetarium, 4D interactive theater, and an observatory. The State Museum is located along the banks of the Congaree River in downtown Columbia, South Carolina. It is the largest museum in the state, and is a Smithsonian Affiliate and part of the American Alliance of Museums. Positioned on an old shipping canal that dates back to pre-Civil War times, the museum is widely recognized as a resource for South Carolina history and lifestyle. The museum opened on October 29, 1988, and is housed in what it calls its largest artifact the former Columbia Mills Building, listed on the National Register of Historic Places in 1982. When the mill opened in 1894, manufacturing cotton duck cloth, it was the first completely electric textile mill in the world. It was also the first major industrial installation for the General Electric corporation. On certain levels of the museum, the original flooring has been kept intact, distinguishable by the textile brads and rings that became embedded in the floor while it was still being used as a mill. The South Carolina Confederate Relic Room & Military Museum is located within the Columbia Mills Building and is the oldest museum exhibit in Columbia.

The Best Friend of Charleston was a steam-powered railroad locomotive widely considered the first locomotive to be built entirely within the United States for revenue service. It was also the first locomotive to suffer a boiler explosion in the United States.