The South Coast of Massachusetts is the region of southeastern Massachusetts consisting of the southern Bristol and Plymouth counties, bordering Buzzards Bay, and includes the cities of Fall River, New Bedford, the southeastern tip of East Taunton and nearby towns. The Rhode Island towns of Tiverton and Little Compton, located in Newport County, are often included within the South Coast designation due to regional similarities with adjacent communities.

Buzzards Bay is a bay of the Atlantic Ocean adjacent to the U.S. state of Massachusetts. It is approximately 28 miles long by 8 miles wide. It is a popular destination for fishing, boating, and tourism. Buzzards Bay is often considered the finest sailing location on the East Coast and is frequently compared in terms of sailing conditions to San Francisco Bay. Since 1914, Buzzards Bay has been connected to Cape Cod Bay by the Cape Cod Canal. In 1988, under the Clean Water Act, the Environmental Protection Agency and the Commonwealth of Massachusetts designated Buzzards Bay to the National Estuary Program, as "an estuary of national significance" that is threatened by pollution, land development, or overuse.