South Dakota Highway 20 (SD 20) is a 385.079-mile (619.725 km) state highway in northern South Dakota, United States, that connects the Montana state line, west-southwest of Camp Crook, with the Minnesota state line, east-southeast of Revillo, via Buffalo, Bison, Timber Lake, Mobridge, Selby, and Watertown. From Mobridge to the Walworth–Potter county line, this highway is part of the Lewis and Clark Trail. From about Timber Lake to just west of Mobridge, this highway is part of the Native American Scenic Byway. From the Montana state line to Camp Crook, the highway is a dirt road.

Watertown is a city in and the county seat of Codington County, South Dakota, United States. Watertown is home to the Redlin Art Center, which houses many of the works of Terry Redlin, one of the nation's most popular wildlife artists. Watertown is between Pelican Lake and Lake Kampeska, from which Redlin derived inspiration for his artwork.