South Dakota Highway 38 is a 63.393-mile (102.021 km) state highway in southeastern South Dakota, United States, that runs from Mitchell to Sioux Falls.

Hanson County is a county in the U.S. state of South Dakota. As of the 2020 census, the population was 3,461. Its county seat is Alexandria. The county was founded in 1871 and organized in 1873. It was named for Joseph R. Hanson, clerk of the first legislature.