South Florida, sometimes colloquially shortened to SoFlo, is the southernmost region of the U.S. state of Florida. It is one of Florida's three most commonly referred to directional regions; the two others are Central Florida and North Florida. South Florida is the southernmost part of the continental United States and the only region of the continental U.S. that includes some areas with a tropical climate.

The Everglades is a natural region of flooded grasslands in the southern portion of the U.S. state of Florida, comprising the southern half of a large drainage basin within the Neotropical realm. The system begins near Orlando with the Kissimmee River, which discharges into the vast but shallow Lake Okeechobee. Water leaving the lake in the wet season forms a slow-moving river 60 miles (97 km) wide and over 100 miles (160 km) long, flowing southward across a limestone shelf to Florida Bay at the southern end of the state. The Everglades experiences a wide range of weather patterns, from frequent flooding in the wet season to drought in the dry season. Throughout the 20th century, the Everglades suffered significant loss of habitat and environmental degradation.