South High School is a public high school located on the south side of Columbus, Ohio. It was opened in 1900 as the fourth Columbus City Schools high school at 345 Deshler Avenue. The current building was opened March 31, 1924. The Charles S. Barrett Building at 345 E. Deshler Ave opened September 1900. Prior to that in 1895-1897 South High School utilized part of the Ohio Avenue Elementary School. In 1897 it was decided that the building was too far east for its name; the south side students were returned to the Central High School building at 6th & Broad Streets, and the building process began on the Deshler Street Building. It was known as South Urban Academy for a short time. The school is located at 1160 Ann Street.

This is a list of public school buildings in Columbus, Ohio, of historical or architectural importance to the Columbus Public School District. Items are listed by opening date.