South Huntington is an affluent hamlet and census-designated place (CDP) within the Town of Huntington in Suffolk County, on Long Island, in New York, United States. The population was 9,422 at the 2010 census. Residents have a Huntington Station postal address. South Huntington is considered part of the greater Huntington area, which is anchored by Huntington.

New York State Route 110 (NY 110) is a major north–south state highway along the western border of Suffolk County, New York. It runs between the village of Amityville in the town of Babylon and Halesite in the town of Huntington. NY 110 comes close to the Nassau County line several times in the town of Babylon, which is only surpassed by NY 108 in distance to the county line for a state highway.