South Padre Island is a resort town in Cameron County, Texas, United States. It is part of the Brownsville–Harlingen Metropolitan Statistical Area. The population was 2,066 at the 2020 census. The town is located on South Padre Island, a barrier island with the Laguna Madre situated to the leeward of the island and the Gulf of Mexico on the windward flank, along the Texas Gulf Coast. South Padre Island is accessible via the Queen Isabella Causeway from the town of Port Isabel. South Padre Island is named after José Nicolás Ballí, a Catholic priest and settler.

Cameron County, officially the County of Cameron, is the southernmost county in the U.S. state of Texas. As of the 2020 census, its population was 421,017. Its county seat is Brownsville.