"South ParQ Vaccination Special" is the second and final episode of the twenty-fourth season of the American animated television series South Park. The 309th episode overall of the series, it premiered on Comedy Central in the United States on March 10, 2021.

The twenty-fourth season of the American animated sitcom South Park is the shortest season of the series, consisting of two extended-length episodes: "The Pandemic Special" and "South ParQ Vaccination Special". The production of the season and the topics of both episodes were shaped by the COVID-19 pandemic.