The South Slave Region is one of five administrative regions in the Northwest Territories of Canada. According to Municipal and Community Affairs the region consists of seven communities with the regional office situated in Fort Smith and a sub-office in Hay River. With the exception of Enterprise and Hay River the communities are predominantly First Nations.

Fort Smith is a town in the South Slave Region of the Northwest Territories (NWT), Canada. It is located in the southeastern portion of the Northwest Territories, on the Slave River and adjacent to the Alberta border along the 60th parallel north.